HTR1F

Overview

HTR1F (5-Hydroxytryptamine Receptor 1F) is a G protein-coupled serotonin receptor. It was identified as a significantly mutated gene exclusive to African American colorectal cancers in a multi-institution sequencing study, forming part of an ethnicity-enriched mutational panel.

Alterations observed in the corpus

• Exclusive to AA CRCs (3/103 vs. 0/129 Caucasian; P=0.086); part of the 20-gene AA-enriched panel in colorectal cancer PMID:25583493

Cancer types (linked)

• CRC: Exclusively mutated in African American CRCs (3/103 vs. 0/129 Caucasian; P=0.086) PMID:25583493

Co-occurrence and mutual exclusivity

• Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

• PMID:25583493

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