IGH
Overview
IGH (Immunoglobulin Heavy locus) encodes the immunoglobulin heavy chain gene cluster on chromosome 14q32. In B-cell malignancies, IGH locus rearrangements are among the most clinically important structural variants: translocation of IGH with MYC (t(8;14)) is the hallmark of Burkitt lymphoma; IGH-BCL2 t(14;18) drives follicular lymphoma and diffuse large B-cell lymphoma (DLBCL); and IGH-BCL1/CCND1 t(11;14) defines mantle cell lymphoma. These translocations place oncogenes under the control of the strong IGH enhancer, driving aberrant expression.
Alterations observed in the corpus
- IGH catalogued as a gene entity in the TCGA pan-cancer fusion atlas (9,624 samples, 33 cancer types including DLBCL), which systematically surveyed gene fusions across RNA-seq data from all major TCGA cancer types. PMID:29617662
Cancer types (linked)
- DLBCL (diffuse large B-cell lymphoma): IGH translocations are a defining feature of several B-cell lymphoma subtypes in the TCGA pan-cancer cohort. PMID:29617662
Co-occurrence and mutual exclusivity
- No specific co-mutation pattern reported for IGH in the corpus.
Therapeutic relevance
Open questions
- The pan-cancer fusion atlas (PMID:29617662) does not report detailed frequency or partner-gene breakdown for IGH fusions; comprehensive fusion calling in DLBCL and other B-cell malignancies requires specialized RNA-seq or WGS approaches tailored to immunoglobulin locus complexity. PMID:29617662
Sources
This page was processed by crosslinker on 2026-05-15.