IL10
Overview
IL10 encodes Interleukin-10, an anti-inflammatory cytokine produced by macrophages, T cells, and B cells. Pro-inflammatory cytokine polymorphisms affecting IL10, IL1B, and TNF modulate H. pylori-induced atrophic gastritis severity and gastric cancer risk.
Alterations observed in the corpus
- Pro-inflammatory polymorphisms in IL10 (high-responder cytokine alleles) amplify H. pylori-driven atrophic gastritis and intestinal metaplasia, increasing gastric cancer risk; may contribute to familial clustering of gastric cancer. PMID:24816255
- Immunosuppressive cytokine up-regulated in anti-PD-1 non-responding pretreatment melanoma tumors in transcriptome analysis PMID:26997480
Cancer types (linked)
- STAD (gastric adenocarcinoma): High-responder IL10 polymorphisms increase H. pylori-associated gastric cancer risk; relevant to familial non-hereditary gastric cancer (FNHGC) susceptibility. PMID:24816255
Co-occurrence and mutual exclusivity
- Co-listed with IL1B and TNF as pro-inflammatory polymorphism loci contributing to H. pylori-driven gastric carcinogenesis. PMID:24816255
Therapeutic relevance
- No direct therapeutic targeting; H. pylori test-and-treat is the key intervention to reduce downstream inflammatory risk.
Open questions
- Polygenic risk scores incorporating IL10 polymorphisms are not yet clinically actionable; interaction with H. pylori strain virulence (cagA) and dietary factors is unresolved.
Sources
This page was processed by entity-page-writer on 2026-05-11. - PMID:26997480
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