IL6ST
Overview
IL6ST encodes gp130 (glycoprotein 130), the shared signal transducer subunit of the IL-6 family cytokine receptors. gp130 mediates signaling for IL-6, IL-11, oncostatin M, and other cytokines through JAK/STAT3 activation. In HCC, IL6ST is listed as a recurrently mutated gene in the mutational landscape.
Alterations observed in the corpus
- IL6ST is listed among recurrently mutated genes in the HCC WES landscape (n=1,289), part of the broader mutational context characterizing the JAK/STAT signaling axis. PMID:24798001
- IL6ST mutations found exclusively in HCC of unknown etiology and mostly restricted to hepatocellular adenomas in non-fibrotic settings; IL6/JAK/STAT pathway altered in 9% of the 243-case European HCC cohort PMID:25822088
Cancer types (linked)
- HCC (hepatocellular carcinoma): Recurrently mutated in HCC cohorts; functional implications for IL-6/JAK/STAT3 signaling in liver cancer. PMID:24798001
Co-occurrence and mutual exclusivity
- Co-listed with JAK1 and other signaling pathway genes in the HCC mutational landscape. PMID:24798001
Therapeutic relevance
- No direct therapeutic targeting of IL6ST reported in this corpus for HCC; JAK inhibitors targeting downstream signaling are under general investigation.
Open questions
- Frequency and functional impact of IL6ST mutations in HCC require dedicated characterization; the paper lists it among recurrently mutated genes without reporting specific mutation frequencies.
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:25822088
This page was processed by crosslinker on 2026-05-14.