IL7R

Overview

IL7R (Interleukin 7 Receptor) encodes the alpha chain of the IL-7 receptor, which signals through JAK1/JAK3 and STAT5 to promote lymphocyte survival and proliferation. In esophageal squamous cell carcinoma (ESCC), focal amplification of IL7R activates JAK-STAT3 signaling, contributing to the oncogenic STAT3 activation observed in this cancer type.

Alterations observed in the corpus

  • Amplification activating JAK-STAT3 signaling in ESCC (139 paired tumor/germline samples by whole-exome/targeted sequencing) PMID:24686850

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • Co-occurs with JAK1 mutations and SOX2 amplification as part of the JAK-STAT3 activation axis in ESCC PMID:24686850

Therapeutic relevance

  • JAK-STAT3 pathway activation via IL7R amplification suggests potential sensitivity to JAK inhibitors in ESCC PMID:24686850

Open questions

Sources

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