INPP4A

Overview

INPP4A (Inositol Polyphosphate-4-Phosphatase Type I A) is a phosphatase involved in PI3K/AKT pathway regulation. It has been identified as one of the top frequently altered genes in upper tract urothelial carcinoma (UTUC).

Alterations observed in the corpus

• Among the top 14 frequently altered genes in upper tract urothelial carcinoma (UTUC); included in the orthogonal MiSeq confirmation panel used to validate MSK-IMPACT findings PMID:26278805

Cancer types (linked)

• Upper tract urothelial carcinoma (UTUC): frequently altered; specific alteration type and exact frequency not reported separately but confirmed by orthogonal sequencing PMID:26278805

Co-occurrence and mutual exclusivity

• Identified alongside chromatin-modifying genes (KDM6A, KMT2D, KMT2A, KMT2C, CREBBP, EP300, ARID1A, SMARCA4), FGFR3, HRAS, TP53, and others in UTUC PMID:26278805

Therapeutic relevance

• No specific therapeutic implications reported; involvement in PI3K pathway regulation may be relevant to PI3K-directed therapy selection PMID:26278805

Open questions

• Specific alteration type (mutation, deletion, amplification) and exact frequency in UTUC not detailed; functional role in urothelial carcinogenesis uncharacterized PMID:26278805

Sources

• PMID:26278805

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