ITGB1

Overview

ITGB1 (Integrin Subunit Beta 1) encodes the beta-1 integrin chain, which pairs with multiple alpha subunits to form integrin heterodimers mediating cell-extracellular matrix adhesion. In cancer, ITGB1 functions as a receptor for ECM components and paracrine signals such as SEMA7A, transducing mechanosensory and pro-invasive signals that promote EMT and cancer stem cell traits.

Alterations observed in the corpus

• Functional SEMA7A receptor on GBC cells; binds SEMA7A via RGD motif (RGD→RGE mutant abolishes binding); neutralizing antibody blocks downstream AKT→EP300 signaling, invasion, EMT, and stemness induction PMID:24997986

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24997986

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