ITK
Overview
ITK (IL2-inducible T-cell kinase) encodes a tyrosine kinase critical for T-cell receptor signaling and T-cell development. In cancer genomics, ITK has been observed in germline sequencing as a variant of uncertain significance (VOUS) in pediatric lymphoma contexts.
Alterations observed in the corpus
- ITK V175V variant of uncertain significance (VOUS) returned to a family with Hodgkin lymphoma and EBV infection in pediatric comprehensive genomic sequencing PMID:28007021.
Cancer types (linked)
- Hodgkin lymphoma: ITK V175V VOUS identified in a pediatric patient with concurrent EBV infection PMID:28007021.
Co-occurrence and mutual exclusivity
- No co-occurrence data reported in the current corpus.
Therapeutic relevance
- No therapeutic actionability established for the V175V VOUS; returned under conservative disclosure criteria in a pediatric tumor board setting PMID:28007021.
Open questions
- The functional significance of ITK V175V and its relationship to Hodgkin lymphoma predisposition or EBV susceptibility remains unresolved PMID:28007021.
Sources
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