JPT1
Overview
JPT1 (Jupiter Microtubule Associated Homolog 1; formerly HN1) encodes a microtubule-associated protein involved in cell cycle regulation. In hepatocellular carcinoma (HCC), JPT1 (previously reported as HN1) is one of five genes in a tumor-expression score that predicts HCC recurrence and survival after surgical resection.
Alterations observed in the corpus
- JPT1 (reported as HN1 in the original literature) is one of 5 genes (alongside TAF9, RAN, RAMP3, KRT19) constituting a tumor score predicting HCC recurrence and survival after resection PMID:24735922
Cancer types (linked)
- HCC — component of a 5-gene prognostic expression signature for post-resection HCC recurrence PMID:24735922
Co-occurrence and mutual exclusivity
- Co-expressed with TAF9, RAN, RAMP3, and KRT19 as part of the HCC 5-gene recurrence prediction signature PMID:24735922
Therapeutic relevance
Open questions
- The 5-gene signature requires prospective validation in independent multi-center cohorts; individual gene contributions are not separately quantified.
Sources
This page was processed by entity-page-writer on 2026-05-11.