JUP
Overview
JUP (Junction Plakoglobin, also known as gamma-catenin) encodes a desmosomal and adherens junction protein that acts as a structural component of cell-cell junctions. In cancer genomics, JUP has been identified as a fusion transcript partner with ERBB2 in esophageal adenocarcinoma.
Alterations observed in the corpus
- JUP 3’-UTR fused to ERBB2 exon 12 in 6 amplified esophageal adenocarcinomas (EACs); the fusion transcript lacks transmembrane and tyrosine-kinase domains PMID:28052061.
Cancer types (linked)
- Esophageal adenocarcinoma (EAC): ERBB2 exon-12–JUP 3’-UTR fusion transcript detected in 6 ERBB2-amplified EACs; the truncated protein product lacks transmembrane and kinase domains PMID:28052061.
Co-occurrence and mutual exclusivity
- JUP fusion occurs in the context of ERBB2 amplification in EAC; ERBB2 is amplified or mutated in 32% of EACs PMID:28052061.
Therapeutic relevance
- The ERBB2–JUP fusion transcript lacks functional domains; therapeutic implications relative to ERBB2 amplification status in the same tumors remain unclear PMID:28052061.
Open questions
- Whether the ERBB2–JUP fusion contributes to oncogenesis or is a byproduct of ERBB2 amplification-associated genomic instability requires further investigation PMID:28052061.
Sources
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