KDM4C

Overview

KDM4C (lysine demethylase 4C) is a histone H3K9/H3K36 demethylase involved in transcriptional regulation and chromatin remodeling. It is recurrently mutated or amplified in several cancer types including prostate cancer.

Alterations observed in the corpus

• Chromatin-modifier mutation identified in MSK prostate cancer cell lines, consistent with Grasso 2012 CRPC findings PMID:25201530
• Focal chromosome-9 deletion removing the promoter/5′ end; statistically significant in ampullary adenocarcinoma (AMPAC); deletion lowered expression of both KDM4C and upstream UHRF2; KDM4C complexes with β-catenin, implicating WNT pathway interaction PMID:26804919

Cancer types (linked)

• Prostate cancer (CRPC): recurrent chromatin modifier mutation.

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25201530

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