KDM4D

Overview

KDM4D (lysine demethylase 4D) is a histone H3K9/H3K36 demethylase in the KDM4 family. It participates in chromatin remodeling and transcriptional regulation, and is recurrently mutated in prostate cancer.

Alterations observed in the corpus

• Chromatin-modifier mutation identified in MSK prostate cancer cell lines, consistent with Grasso 2012 CRPC findings PMID:25201530

Cancer types (linked)

• Prostate cancer (CRPC): recurrent chromatin modifier mutation.

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25201530

This page was processed by entity-page-writer on 2026-05-11.