KLHL6

Overview

KLHL6 (Kelch-Like Family Member 6) encodes a substrate adaptor for the BCR-ABL1 E3 ubiquitin ligase complex involved in B-cell receptor signaling. In cancer genomics, KLHL6 mutations in DLBCL show mutual exclusivity with TP53 mutations, suggesting non-overlapping functional roles in lymphomagenesis.

Alterations observed in the corpus

  • Mutually exclusive with TP53 mutations in DLBCL (1001-patient cohort treated with rituximab-containing regimens); TP53 is CRISPR-enriched (loss increases fitness) while KLHL6 shows a distinct pattern. PMID:28985567

Cancer types (linked)

  • DLBCL NOS: KLHL6 mutations are part of the 150 recurrently mutated driver gene landscape in DLBCL; mutual exclusivity with TP53 is a defining co-mutation pattern in this study. PMID:28985567

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct targeted therapy against KLHL6 is reported in this corpus.

Open questions

  • The mechanistic basis of KLHL6 and TP53 mutual exclusivity in DLBCL pathogenesis is not detailed; whether they represent convergent or divergent oncogenic pathways requires functional investigation. PMID:28985567

Sources

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