LAMA5

Overview

LAMA5 encodes laminin subunit alpha 5, a large extracellular matrix glycoprotein and component of basement membrane laminins. Laminins mediate cell adhesion, migration, and signaling. High-level somatic copy-number amplification of LAMA5 has been reported in cutaneous squamous cell carcinoma, where it represents the most recurrently high-level amplified candidate oncogene.

Alterations observed in the corpus

  • LAMA5 is the most recurrently high-level amplified oncogene in metastatic cSCC (4/29 samples with high-level amplification), identified by GISTIC analysis of targeted sequencing data (OncoPanelv2, 504 genes) from 29 lymph-node metastases. PMID:25589618

Cancer types (linked)

  • CSCC: High-level copy-number amplification in 4/29 (14%) metastatic cSCC lymph-node metastases; the biological significance and mechanism are not yet established. PMID:25589618

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

  • Whether LAMA5 amplification drives oncogenic signaling or is a passenger event within a broader amplicon requires functional validation. PMID:25589618

Sources

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