LANCL2
Overview
LANCL2 (LanC Like 2) encodes a mammalian homologue of bacterial LanC cyclases, implicated in metabolic sensing and immune modulation. In the cancer genomics context, LANCL2 has emerged as a recurrently deleted locus in glioblastoma, suggesting a potential tumor-suppressor role in GBM.
Alterations observed in the corpus
- Recurrently deleted locus in GBM; identified as a focal deletion target in the TCGA multi-platform GBM analysis (n=543) PMID:24120142
Cancer types (linked)
- GBM — focal deletion observed; specific prevalence not independently quantified from GISTIC peak in cohort of 543 primary GBM PMID:24120142
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data currently in corpus.
Therapeutic relevance
- No direct therapeutic data currently in corpus.
Open questions
- Functional significance of LANCL2 deletion in GBM pathogenesis is unresolved.
Sources
This page was processed by crosslinker on 2026-05-09.