LLGL1

Overview

LLGL1 (Lethal Giant Larvae Homolog 1) is a tumor suppressor gene involved in cell polarity and asymmetric cell division. It encodes a component of the LLGL/Scribble polarity complex and has been implicated in suppression of tumor invasion and metastasis in several cancer contexts.

Alterations observed in the corpus

• 2 missense mutations identified in uveal melanoma WGS cohort (n=28); flagged as a plausible additional candidate driver based on tumor-suppressor roles in other cancers but without functional validation PMID:26683228

Cancer types (linked)

• Uveal melanoma: recurrent missense mutations; candidate driver status, functional significance unconfirmed PMID:26683228

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional significance of LLGL1 missense mutations in uveal melanoma remains uncharacterized; larger cohorts needed PMID:26683228

Sources

• PMID:26683228

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