LRP1

Overview

LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) encodes a large endocytic receptor involved in lipid metabolism, cell signaling, and cellular entry of various ligands. Recurrent somatic mutations in LRP1 have been observed in anaplastic thyroid carcinoma (ATC).

Alterations observed in the corpus

• Recurrent mutations previously described in anaplastic thyroid carcinoma (ATC); identified in a multi-site consortium WES/WGS study of 137 ATCs PMID:38412093.

Cancer types (linked)

• Anaplastic thyroid carcinoma (ATC) — recurrent somatic mutations; specific functional impact not characterized in this corpus PMID:38412093.

Co-occurrence and mutual exclusivity

• Not specifically reported in the corpus.

Therapeutic relevance

• No direct therapeutic link reported in the corpus.

Open questions

• The functional consequence of LRP1 mutations in ATC (tumor suppressor vs. passenger) requires experimental validation.

Sources

• PMID:38412093

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