LRP1B

Overview

One-paragraph summary of the gene’s role and why it matters in cancer genomics.

Alterations observed in the corpus

• Mutation classes (missense / truncating / fusion / amplification / deletion) with links to the papers that report them.
• 17 mutations in 188 LUAD tumours; positive correlation with solid histological subtype (P=2.29e-5) and higher tumour grade (P=0.013); part of Wnt pathway. PMID:18948947
• Deleted in the copy-number-high (cluster-4, serous-like) endometrial carcinoma subgroup; recently associated with liposomal doxorubicin resistance in serous ovarian cancer PMID:23636398
• Recurrent single-gene focal deletion target in GBM; identified as a focal deletion locus in TCGA multi-platform GBM analysis (n=543) PMID:24120142

Cancer types (linked)

• Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

• Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:18948947

This page was processed by crosslinker on 2026-05-09. - PMID:23636398

This page was processed by crosslinker on 2026-05-09. - PMID:24120142

This page was processed by crosslinker on 2026-05-09.