LSAMP

Overview

LSAMP (Limbic System-Associated Membrane Protein) is a GPI-anchored cell-adhesion molecule expressed in the limbic system. In cancer genomics, LSAMP maps to 3q13.3 and has been identified as a recurrently focally deleted locus in glioblastoma, consistent with a tumor-suppressor role.

Alterations observed in the corpus

  • Single-gene focal deletion target in GBM; identified as a focal deletion locus in the TCGA multi-platform GBM analysis (n=543) PMID:24120142

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • No co-occurrence or mutual exclusivity data currently in corpus.

Therapeutic relevance

  • No direct therapeutic data currently in corpus.

Open questions

  • Functional role of LSAMP loss in gliomagenesis requires experimental validation.

Sources

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