MAGEA6

Overview

MAGEA6 (Melanoma Antigen Gene A6) is a cancer/testis antigen gene belonging to the MAGE-A family. It is normally expressed in the testis and silent in somatic tissues, but aberrantly expressed in a variety of tumor types. It was identified as one of 16 significantly mutated genes in pancreatic ductal adenocarcinoma by ICGC whole-exome sequencing, representing a novel somatic driver in that cancer type.

Alterations observed in the corpus

• One of 16 significantly mutated genes in pancreatic ductal adenocarcinoma (ICGC, 142 tumors); novel finding in this tumor type PMID:23103869

Cancer types (linked)

• PAAD — identified as a significantly mutated gene in ICGC pancreatic cancer WES cohort (142 tumors) PMID:23103869

Co-occurrence and mutual exclusivity

• None reported in this corpus.

Therapeutic relevance

• No direct therapeutic targeting reported in this corpus.

Open questions

• Functional role of MAGEA6 mutations in pancreatic cancer pathogenesis remains undefined.

Sources

• PMID:23103869

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