MAGEB10

Overview

MAGEB10 (MAGE family member B10) belongs to the cancer-testis antigen (CTA) MAGE-B subfamily, which are normally restricted to germline expression but are aberrantly activated in various cancers. MAGE family members interact with ubiquitin ligase complexes and have roles in apoptosis regulation and cell cycle control.

Alterations observed in the corpus

  • MAGEB10 was identified as one of 20 significantly mutated genes in African American (AA) colorectal cancers; part of a 15-gene subset preferentially mutated in AA vs Caucasian MSS CRC (~41% of AA CRCs vs 15% of Caucasian CRCs; discovery n=29, validation n=74 AA CRC, comparator n=129 Caucasian CRC). PMID:25583493

Cancer types (linked)

  • COAD: MAGEB10 is a newly identified significantly mutated gene in AA MSS colorectal cancer; its functional role as a driver versus passenger remains to be established. PMID:25583493

Co-occurrence and mutual exclusivity

  • Mutational pattern consistent with the broader 15-gene AA-enriched CRC driver panel; relationship to canonical CRC drivers (APC, TP53, KRAS) not separately analyzed. PMID:25583493

Therapeutic relevance

Open questions

  • Functional consequence of MAGEB10 somatic mutations in CRC and whether AA-specific enrichment reflects ethnicity-specific mutational processes or founder effects requires further investigation. PMID:25583493

Sources

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