MAP2K7
Overview
MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7), also known as MKK7, is a dual-specificity protein kinase in the JNK signaling cascade that phosphorylates and activates JNK kinases. It plays roles in stress responses, apoptosis, and cell proliferation. Somatic mutations in MAP2K7 have been identified as candidate RAS-pathway drivers in colorectal cancer.
Alterations observed in the corpus
- MAP2K7 nominated as a RAS-pathway kinase CRC driver in a 619-tumor whole-exome sequencing study (NHS/HPFS cohort) PMID:27149842
Cancer types (linked)
- Colorectal cancer: newly nominated as a significantly mutated gene (RAS-pathway kinase driver) PMID:27149842
Co-occurrence and mutual exclusivity
- Nominated alongside MAP2K1 and PRKCQ as RAS-pathway kinase drivers in CRC PMID:27149842
Therapeutic relevance
- Potential relevance as a RAS-pathway driver in CRC; therapeutic implications not yet established PMID:27149842
Open questions
- Whether MAP2K7 mutations in CRC are functionally activating or inactivating, and whether they confer sensitivity or resistance to MAPK-pathway inhibitors, remains to be determined PMID:27149842
Sources
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