MAP3K15

Overview

MAP3K15 (Mitogen-Activated Protein Kinase Kinase Kinase 15) encodes a serine/threonine kinase in the MAPK signaling cascade. In cancer genomics, inactivating mutations in MAP3K15 have been observed in esophageal squamous cell carcinoma (ESCC).

Alterations observed in the corpus

• MAP3K15 harbors inactivating mutations in ESCC, contributing to MAPK pathway dysregulation PMID:24686850

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24686850

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