MED1

Overview

MED1 (Mediator Complex Subunit 1; also TRAP220, DRIP205) encodes a subunit of the Mediator transcriptional coactivator complex that bridges enhancers and RNA Pol II. It is a known AR coactivator amplified or overexpressed in castration-resistant prostate cancer, and also observed as a chromatin-modifier mutation in CRPC genomics studies.

Alterations observed in the corpus

• Chromatin-modifier mutation observed in patient-derived CRPC organoids consistent with Grasso 2012 CRPC genomic findings PMID:25201530

Cancer types (linked)

• CRPC: chromatin-modifier mutation; co-occurs with AR amplification and PTEN loss in patient-derived organoid models PMID:25201530

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25201530

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