MGA

Overview

MGA is a MAX-interacting transcriptional repressor in the MYC/MAX/MXD network, frequently inactivated in lung adenocarcinoma.

Altered more often in LUAD metastases than in matched primaries PMID:37084736.
High-risk small bowel GIST class in the elastic-net Cox genomic risk model was defined by alterations in any of MAX/MGA/MYC, CDKN2A, or RB1 PMID:37477937.
Mutation observed in ACC; MGA is a MYB-pathway gene PMID:23685749
Single frameshift mutation identified in the sequenced sinonasal adenoid cystic carcinoma cohort; categorized among single-case minor gene hits PMID:24418857
MGA loss-of-function (frameshift/nonsense) mutations in 8% of LUAD (TCGA, n=230); mutually exclusive with focal MYC amplification (Fisher’s exact P=0.04); encodes a Max-interacting protein; nominated as significantly mutated gene by MutSig2CV PMID:25079552
Recurrent truncating insertions and nonsense mutations in n=17 (3.2%) of 538 CLL cases; MYC suppressor; RNA-seq shows derepression of MYC-suppressed B-cell programs in MGA-mutant CLL PMID:26466571
Transcriptional-regulator gene with mutations enriched in the DUX4/ERG B-ALL subtype relative to 209 other B-ALL and 16 T-ALL comparator cases PMID:27776115
MGA was identified as one of 150 DLBCL driver genes, and its knockout in a CRISPR screen was enriched (consistent with a tumor suppressor function) across DLBCL cell lines; MGA was one of 27 genes not previously implicated in DLBCL PMID:28985567

LUAD — metastasis-enriched alteration in the MSK organotropism cohort (n=2,532) PMID:37084736.

This page was processed by crosslinker on 2026-05-14. - PMID:23685749

This page was processed by crosslinker on 2026-05-14. - PMID:24418857

This page was processed by crosslinker on 2026-05-14. - PMID:25079552

This page was processed by crosslinker on 2026-05-14. - PMID:26466571

This page was processed by crosslinker on 2026-05-14. - PMID:27776115

This page was processed by entity-page-writer on 2026-05-15. - PMID:28985567

This page was processed by wiki-cli on 2026-05-15.