MGAT4C

Overview

MGAT4C (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C) encodes a Golgi glycosyltransferase involved in N-glycan biosynthesis. Alterations in glycosylation enzymes can affect cell-surface receptor signaling and cell adhesion, with potential oncogenic consequences.

Alterations observed in the corpus

  • MGAT4C was identified as one of 20 significantly mutated genes in African American (AA) colorectal cancers; part of the 15-gene subset preferentially mutated in AA vs Caucasian MSS CRC (~41% AA CRCs vs 15% Caucasian CRCs; discovery n=29 + validation n=74 AA CRC, comparator n=129 Caucasian CRC). PMID:25583493

Cancer types (linked)

  • COAD: MGAT4C is a newly identified significantly mutated gene in AA MSS colorectal cancer; its contribution to CRC pathogenesis is not yet functionally characterized. PMID:25583493

Co-occurrence and mutual exclusivity

  • Part of the broader 15-gene AA-enriched CRC driver panel; relationship to canonical CRC drivers not separately analyzed. PMID:25583493

Therapeutic relevance

Open questions

  • Whether MGAT4C mutations alter glycosylation patterns on specific oncogenic substrates in CRC, and the mechanism of AA-specific enrichment, require functional investigation. PMID:25583493

Sources

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