MICA

Overview

MICA (MHC Class I Polypeptide-Related Sequence A) encodes an NKG2D ligand involved in immune surveillance. In cancer genomics, MICA has been identified as a GWAS susceptibility locus associated with hepatocellular carcinoma (HCC) risk, particularly in the context of viral hepatitis (HBV/HCV).

Alterations observed in the corpus

MICA is a GWAS susceptibility locus/SNP associated with HBV- or HCV-related HCC risk PMID:24735922

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

PMID:24735922

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