MIR17HG
Overview
MIR17HG (miR-17-92 host gene, also known as C13orf25) encodes the miR-17~92 polycistronic microRNA cluster, a key oncogenic miRNA cluster that promotes cell proliferation, inhibits apoptosis, and is frequently amplified in multiple cancers. In rhabdomyosarcoma it is amplified in the PAX-FOXO1 fusion-positive subset.
Alterations observed in the corpus
- 13q31-32 amplification detected exclusively in fusion-positive (PFP) ARMS rhabdomyosarcoma (4.5% of PFP tumors); also recurrently SV-affected in the same subset, suggesting a PAX7-FOXO1-associated oncogenic role PMID:24436047
Cancer types (linked)
- RMS (Rhabdomyosarcoma): Amplification restricted to fusion-positive PAX-FOXO1 ARMS subset; not observed in fusion-negative RMS PMID:24436047
Co-occurrence and mutual exclusivity
- Co-amplified in PAX7-FOXO1-positive ARMS tumors; the MIR17HG amplicon at 13q31-32 may reinforce PAX7-FOXO1 oncogenic signaling PMID:24436047
Therapeutic relevance
- No targeted therapy established; amplification identifies a genomic subgroup of ARMS that may have distinct biology.
Open questions
- Whether MIR17HG amplification is a driver or passenger in the PAX-FOXO1 ARMS context remains unresolved.
Sources
This page was processed by crosslinker on 2026-05-09.