MIR205

Overview

MIR205 (MicroRNA 205) is a microRNA with context-dependent roles in cancer. In squamous cell carcinomas, including lung SqCC, MIR205 is frequently amplified and may function as an oncogene by suppressing tumor suppressor targets. In other cancer types it acts as a tumor suppressor. The TCGA pan-lung cancer analysis identified MIR205 as a novel focal amplification target specific to lung squamous cell carcinoma.

Alterations observed in the corpus

• MIR205 is a novel focal amplification target in lung squamous cell carcinoma identified in pan-lung cancer TCGA analysis (n=1144) PMID:27158780

Cancer types (linked)

• Lung squamous cell carcinoma: focal amplification of MIR205 locus PMID:27158780

Co-occurrence and mutual exclusivity

• No co-occurrence or mutual exclusivity patterns reported in the corpus.

Therapeutic relevance

• MIR205 amplification in lung SqCC may represent a subtype-specific oncogenic driver; therapeutic implications not yet established PMID:27158780

Open questions

• Whether the MIR205 focal amplification is a primary driver event or a passenger in lung SqCC requires functional validation PMID:27158780

Sources

• PMID:27158780

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