MN1

Overview

MN1 (MN1 Proto-Oncogene, Transcriptional Regulator) encodes a transcriptional regulator initially identified at the translocation breakpoint of meningioma. It is most prominently associated with astroblastoma, where MN1::BEND2 fusions define an epigenetic subtype of this rare brain tumor. MN1 is referenced in the context of EWSR1::BEND2 fusion sarcomas as the canonical fusion partner that is replaced by EWSR1 in non-CNS presentations.

Alterations observed in the corpus

  • MN1 discussed as the canonical fusion partner in astroblastoma; MN1::BEND2 fusions characterize an epigenetic subtype of astroblastoma to which an EWSR1::BEND2 bladder sarcoma showed weak methylation classifier similarity (prediction score 0.364); the EWSR1 breakpoint in the bladder sarcoma case (exon 10) differs from those in MN1::BEND2 / EWSR1::BEND2 astroblastomas PMID:28199314

Cancer types (linked)

  • ASTB (Astroblastoma): MN1::BEND2 fusions are the defining alteration of an epigenetic subtype of astroblastoma; typically replacing each other in CNS vs. non-CNS contexts when EWSR1::BEND2 is found PMID:28199314
  • EWS / Undifferentiated Small Round Cell Sarcoma: MN1 is discussed as a comparator to contextualize EWSR1::BEND2 bladder sarcoma within the WHO classification of EWSR1-non-ETS fusion neoplasms PMID:28199314

Co-occurrence and mutual exclusivity

  • MN1::BEND2 and EWSR1::BEND2 fusions appear mutually exclusive within astroblastoma subtypes, with EWSR1::BEND2 fusions described in CNS cases sharing molecular similarity with MN1-rearranged astroblastomas PMID:28199314

Therapeutic relevance

  • No direct therapeutic targeting of MN1 is proposed in this corpus; MN1 status is primarily diagnostic and taxonomic.

Open questions

  • Whether EWSR1::BEND2 sarcomas outside the CNS (e.g., bladder) form a distinct molecular subgroup from MN1::BEND2 / EWSR1::BEND2 astroblastomas remains unresolved; the differing EWSR1 breakpoint (exon 10 in bladder vs. exons reported in CNS cases) raises this question PMID:28199314

Sources

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