MT1H

Overview

MT1H is a metallothionein family isoform involved in metal homeostasis and cellular stress responses. In HER2+ metastatic esophagogastric cancer, MT1H expression was identified by single-cell RNA-seq as part of a resistance transcriptional program to trastuzumab-based therapy.

Alterations observed in the corpus

  • MT1H expression associated with trastuzumab + chemotherapy resistance by scRNA-seq in HER2+ esophagogastric cancer (EGC) escape lesions; identified alongside MT1E, MT2A, and MSMB as candidate future therapeutic targets PMID:37406106.

Cancer types (linked)

  • Esophagogastric cancer (HER2+) — MT1H expressed in resistance subpopulations at progression on trastuzumab-based therapy PMID:37406106.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • MT1H is a candidate future therapeutic target; requires orthogonal preclinical validation PMID:37406106.

Open questions

  • The functional mechanism by which MT1H contributes to trastuzumab resistance is not experimentally established.

Sources

This page was processed by crosslinker on 2026-05-04.