MUC12

Overview

MUC12 (Mucin 12, Cell Surface Associated) is a transmembrane mucin involved in epithelial cell protection and signaling. In adenoid cystic carcinoma, exclusive mutations in the MYB-NFIB fusion molecular subclass have been reported.

Alterations observed in the corpus

• Exclusive somatic mutation in the MYB-NFIB fusion group in adenoid cystic carcinoma (ACC); functional significance requires validation PMID:26631609

Cancer types (linked)

• Adenoid cystic carcinoma: exclusive somatic mutation in the MYB-NFIB molecular subclass PMID:26631609

Co-occurrence and mutual exclusivity

• Mutations exclusive to MYB-NFIB fusion group in ACC; not observed in MYBL1-fusion or fusion-negative subclasses PMID:26631609

Therapeutic relevance

Open questions

• Oncogenic role and clinical significance require validation in larger ACC cohorts PMID:26631609

Sources

• PMID:26631609

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