MUC3A

Overview

MUC3A (Mucin 3A, Cell Surface Associated) is an intestinal-type transmembrane mucin. In uveal melanoma, recurrent missense mutations have been observed but lack functional support for driver status.

Alterations observed in the corpus

• 2 missense mutations identified in uveal melanoma WGS cohort (n=28); flagged as recurrent but without functional support PMID:26683228

Cancer types (linked)

• Uveal melanoma: recurrent missense mutations; candidate status unconfirmed PMID:26683228

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional significance of MUC3A missense mutations in uveal melanoma is uncharacterized; larger cohorts needed PMID:26683228

Sources

• PMID:26683228

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