MX1
Overview
MX1 (MX Dynamin-Like GTPase 1) is an interferon-inducible gene that encodes a GTPase involved in antiviral defense. As part of the interferon-related DNA damage resistance signature (IRDS), MX1 upregulation in cancer cells has been linked to resistance to DNA-damaging therapies including chemotherapy.
Alterations observed in the corpus
- IFN-inducible protein forming discrete puncta in serous tubal intraepithelial carcinoma stage C (STIC.C) and cancer epithelial cells; also part of the IRDS signature; co-expressed with HLA-A in STIC.C and cancer cells in HGSOC precursors PMID:39386723.
Cancer types (linked)
- High-grade serous ovarian carcinoma (HGSOC) precursors (STIC) — MX1 upregulated as part of IRDS in STIC.C and cancer; IRDS emergence may contribute to chemoresistance observed in >80% of stage III/IV HGSOC PMID:39386723.
Co-occurrence and mutual exclusivity
- Co-expressed with HLA-A, MCL1, and other IRDS/IFN-stimulated genes in STIC.C and HGSOC cancer cells; part of a coordinated interferon response PMID:39386723.
Therapeutic relevance
- Chronic IFN activation and IRDS signature (including MX1) in STIC.C and cancer may represent a mechanism of chemoresistance in advanced HGSOC PMID:39386723.
Open questions
- The causal relationship between MX1/IRDS upregulation and clinical chemoresistance in HGSOC is correlative; prospective studies are needed.
Sources
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