MYO3A

Overview

MYO3A (Myosin IIIA) is an actin-based motor protein involved in cytoskeletal organization and cell motility. Somatic mutations in MYO3A were identified in triple-negative breast cancer (TNBC) whole-genome sequencing with statistical evidence of positive selection, suggesting a potential driver role. The mechanistic basis for its involvement in cancer is not yet fully characterized.

Alterations observed in the corpus

  • MYO3A somatic mutations found in 9.2% (6/65) of TNBC tumors in BCCRC WGS cohort; positive selection inferred (q < 0.1) PMID:22495314

Cancer types (linked)

  • TNBC (Triple-Negative Breast Cancer): Recurrently mutated in 6/65 WGS tumors with evidence of positive selection PMID:22495314

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No therapeutic agents targeting MYO3A are described in the corpus.

Open questions

  • Whether MYO3A mutations alter cytoskeletal dynamics to promote invasion and metastasis, or act through other mechanisms in TNBC, requires functional validation.

Sources

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