NALCN
Overview
NALCN (Sodium Leak Channel, Non-Selective) encodes a sodium leak channel that regulates resting membrane potential and neuronal excitability. It was identified as one of 16 significantly mutated genes in pancreatic ductal adenocarcinoma by ICGC whole-exome sequencing, making it a novel somatic driver in that cancer type. Its precise role in pancreatic cancer biology is not yet established.
Alterations observed in the corpus
- One of 16 significantly mutated genes in pancreatic ductal adenocarcinoma (ICGC, 142 tumors); mechanism of oncogenic contribution is unknown PMID:23103869
Cancer types (linked)
- PAAD — identified as a significantly mutated gene in ICGC pancreatic cancer WES cohort (142 tumors) PMID:23103869
Co-occurrence and mutual exclusivity
- None reported in this corpus.
Therapeutic relevance
- No direct therapeutic targeting reported in this corpus.
Open questions
- Functional consequence of NALCN mutations in pancreatic cancer is unclear; canonical role in ion channel biology has not been linked to canonical oncogenic pathways.
Sources
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