NEK5

Overview

NEK5 (NIMA Related Kinase 5) is a serine/threonine kinase of the NEK family involved in mitotic regulation. In cancer genomics, it has been identified as a fusion partner in structural rearrangements affecting the TERT promoter region in chromophobe renal cell carcinoma.

Alterations observed in the corpus

• Partner gene in the one inter-chromosomal TERT-promoter structural rearrangement on chromosome 13 in chromophobe RCC; rearrangement associated with >500-unit TERT expression upregulation PMID:25155756

Cancer types (linked)

• ChRCC: structural rearrangement partner with TERT promoter region PMID:25155756

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25155756

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