NEUROD1
Overview
NEUROD1 (Neuronal Differentiation 1) is a basic helix-loop-helix (bHLH) transcription factor involved in neuronal differentiation and development. In IDH-mutant gliomas, the NEUROD1 DNA sequence motif is enriched at treatment-associated hypomethylated CpG sites, suggesting a role in the epigenetic evolution driven by alkylating chemotherapy and/or radiotherapy.
Alterations observed in the corpus
- NEUROD1 DNA sequence motif enriched at treatment-associated hypomethylated CpGs in IDH-mutant gliomas undergoing epigenetic evolution after temozolomide and/or radiotherapy; the motif enrichment suggests NEUROD1 binding may be facilitated by treatment-induced demethylation PMID:38117484.
Cancer types (linked)
- IDH-mutant glioma (astrocytoma, diffuse glioma) — NEUROD1 motif enrichment at treatment-associated hypomethylated loci; implies potential role in the transcriptional consequences of epigenetic remodeling PMID:38117484.
Co-occurrence and mutual exclusivity
- NEUROD1 motif enrichment co-occurs with the broader epigenetic evolution pattern (GCIMP-high to GCIMP-low transition) seen in treated IDH-mutant gliomas PMID:38117484.
Therapeutic relevance
- The role of NEUROD1 in treatment-induced epigenetic remodeling is inferential; no direct therapeutic implications are reported in the corpus.
Open questions
- Whether NEUROD1 binding at demethylated loci is a driver of aggressive transcriptional programs or a consequence of chromatin opening requires experimental validation.
Sources
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