NFKB1

Overview

NFKB1 encodes a subunit of the NF-kB transcription factor complex. In the cbio-kb corpus it is nominated as a novel U-CLL driver linked to NF-kB signaling and adverse outcomes.

Alterations observed in the corpus

• U-CLL-specific novel driver in the 1,148-patient CLL map; recurrent somatic mutations linked to NF-kB signaling and adverse FFS/OS PMID:35927489.

Cancer types (linked)

• Chronic lymphocytic leukemia (CLLSLL) — novel U-CLL driver; candidate addition to CLL risk models PMID:35927489.

Co-occurrence and mutual exclusivity

• Enriched in IGHV-unmutated (U-CLL) subtype relative to M-CLL PMID:35927489.

Therapeutic relevance

• No direct therapeutic link reported in the corpus.

Open questions

• Functional validation as a CLL driver is deferred to future work PMID:35927489.

Sources

• PMID:35927489

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