NFKBIE

Overview

NFKBIE encodes IkB-epsilon, an inhibitor of NF-kB signaling. In the corpus it appears as a recurrent low-frequency driver in CLL and as an NF-kB pathway driver in classic Hodgkin lymphoma.

Alterations observed in the corpus

  • Known lower-frequency CLL driver, reconfirmed as prognostic in U-CLL in the 1,148-patient CLL map PMID:35927489.
  • Mutated in 15% of classic Hodgkin lymphoma cases profiled by WGS/WES (n=61); NF-kB pathway driver PMID:36723991.
  • Novel recurrent promoter hotspot mutations in 14.5% of desmoplastic melanoma samples (9 at primary site, 2 at nearby secondary site); plus focal amplification in 2 tumors; biallelic selection demonstrated; loss of NFκB nuclear translocation in mutant cell lines, suggesting gain-of-function event suppressing NFκB signaling. PMID:26343386

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic link reported in the corpus.

Open questions

  • Mechanistic role relative to other NF-kB drivers across B-cell malignancies remains open.

Sources

This page was processed by crosslinker on 2026-04-08. - PMID:26343386

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