NGFR

Overview

NGFR (Nerve Growth Factor Receptor; also p75NTR) encodes a low-affinity neurotrophin receptor involved in neural differentiation, apoptosis, and cell survival. In cancer genomics, it is an established transcriptional target of the EWS::FLI1 fusion oncogene in Ewing sarcoma, consistent with the neural/mesenchymal identity of that tumor type.

Alterations observed in the corpus

• Established EWS::FLI1 transcriptional target; induced upon EWS::FLI1 expression in human embryonic mesenchymal stem cells (heMSCs) and validated by RT-qPCR in Ewing sarcoma cell-of-origin study PMID:25186949
• KIAA1737–NGFR in-frame fusion identified in pheochromocytoma/paraganglioma, resulting in 3.0-fold NGFR overexpression PMID:28162975

Cancer types (linked)

• Ewing sarcoma: EWS::FLI1-driven transcriptional target; expression reflects oncogene activity PMID:25186949

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25186949

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