NHERF1
Overview
NHERF1 (Na+/H+ exchanger regulatory factor 1, also known as EBP50) is a scaffold protein involved in receptor signaling. It was newly nominated as a significantly mutated gene in papillary renal cell carcinoma (pRCC) in a multisubtype non-clear-cell RCC genomic study.
Alterations observed in the corpus
- Newly nominated significantly mutated gene in pRCC in a multisubtype nccRCC WES study PMID:25401301
Cancer types (linked)
- pRCC: significantly mutated in discovery cohort; functional characterization not yet established PMID:25401301
Co-occurrence and mutual exclusivity
- Co-nominated with NF2, SLC5A3, PNKD, CPQ, LRP2, CHD3, SETD2, and CRTC1 as significantly mutated genes in pRCC PMID:25401301
Therapeutic relevance
- No targeted therapies established; oncogenic versus passenger status unresolved PMID:25401301
Open questions
- NHERF1 lacks functional characterization in pRCC — oncogenic vs passenger status is unestablished PMID:25401301
Sources
This page was processed by entity-page-writer on 2026-05-11.