NPAS3

Overview

NPAS3 (Neuronal PAS Domain Protein 3) is a basic helix-loop-helix/PAS domain transcription factor expressed predominantly in the brain. It maps to 14q13 and has been implicated in neuropsychiatric disorders. In glioblastoma, NPAS3 has been identified as a recurrent single-gene focal deletion target, suggesting a tumor-suppressor function in GBM.

Alterations observed in the corpus

  • Single-gene focal deletion target in GBM; identified as a focal deletion locus in the TCGA multi-platform GBM analysis (n=543) PMID:24120142

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • No co-occurrence or mutual exclusivity data currently in corpus.

Therapeutic relevance

  • No direct therapeutic data currently in corpus.

Open questions

  • Functional role of NPAS3 loss in gliomagenesis and its potential interaction with RTK or cell-cycle pathways are unresolved.

Sources

This page was processed by crosslinker on 2026-05-09.