NR0B1

Overview

NR0B1 (Nuclear Receptor Subfamily 0 Group B Member 1; also DAX1) encodes an atypical nuclear receptor that acts as a transcriptional repressor. In cancer genomics, it is an established transcriptional target of the EWS::FLI1 fusion oncogene in Ewing sarcoma, marking cells with oncogene activity.

Alterations observed in the corpus

• Established EWS::FLI1 transcriptional target; induced upon EWS::FLI1 expression in heMSCs and validated by RT-qPCR as a Ewing sarcoma marker PMID:25186949

Cancer types (linked)

• Ewing sarcoma: EWS::FLI1-driven transcriptional target PMID:25186949

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25186949

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