NR3C1

Overview

NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1), also known as the glucocorticoid receptor (GR), is a ligand-activated transcription factor in the nuclear receptor superfamily. Somatic mutations in NR3C1 were identified in triple-negative breast cancer (TNBC) by whole-genome sequencing and ranked highly in driverNet network analysis, suggesting a potential driver role in a subset of TNBC.

Alterations observed in the corpus

  • NR3C1 SNVs detected in 3 of 65 TNBC tumors (BCCRC WGS cohort); driverNet rank 10 among candidate drivers PMID:22495314
  • NR3C1 (glucocorticoid receptor, GR) expression was identified in AR-low/AR-absent mCRPC tumors as a potential substitute driver for AR transcriptional output, alongside ESR1; GR may sustain AR-pathway signaling in the absence of AR protein expression PMID:26928463

Cancer types (linked)

  • TNBC (Triple-Negative Breast Cancer): Somatic point mutations in 3/65 WGS tumors, prioritized by network-based driver analysis PMID:22495314

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Glucocorticoid receptor signaling has been proposed as an escape mechanism in ER-negative breast cancer; NR3C1 mutations may alter this pathway, though no direct therapeutic targeting is described in the corpus.

Open questions

  • Whether NR3C1 mutations confer gain- or loss-of-function, and their relationship to glucocorticoid signaling in TNBC, require functional validation.

Sources

This page was processed by entity-page-writer on 2026-05-06. - PMID:26928463

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