NXF1

Overview

NXF1 (Nuclear RNA Export Factor 1) encodes the major mRNA export receptor in metazoans, mediating bulk poly(A)+ mRNA transport from the nucleus to the cytoplasm. In cancer, NXF1 has been identified as a recurrently mutated driver in chronic lymphocytic leukemia (CLL), belonging to a broader class of RNA processing and export genes disrupted in that disease.

Alterations observed in the corpus

• Identified as a novel CLL driver in the RNA processing and export category in a 538-sample WES cohort (CLL8 trial); recurrently mutated among RNA processing/export drivers PMID:26466571

Cancer types (linked)

• CLL: recurrent somatic mutations identified as a novel driver in WES analysis of the CLL8 chemoimmunotherapy trial cohort PMID:26466571

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26466571

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