OR5L1

Overview

OR5L1 is an olfactory receptor gene identified as one of nine significantly mutated genes (FDR ≤ 0.10) in castration-resistant prostate cancer (CRPC) by whole-exome sequencing. Olfactory receptor genes are frequently mutated in cancers due to their large family size, and their functional significance as cancer drivers remains unclear; OR5L1 has not been functionally validated as a bona fide cancer driver.

Alterations observed in the corpus

Identified as one of nine significantly mutated genes (FDR ≤ 0.10) in prostate cancer WES (Michigan cohort, 112 tumors including 50 CRPCs); functional significance uncharacterised PMID:22722839

Cancer types (linked)

PRAD: Statistical significance mutation in CRPC cohort; not functionally validated as a prostate cancer driver PMID:22722839

Co-occurrence and mutual exclusivity

Co-identified as significantly mutated alongside TP53, AR, ZFHX3, RB1, PTEN, APC, KMT2D, and CDK12 in CRPC PMID:22722839

Therapeutic relevance

No known therapeutic relevance; functional validation has not been performed PMID:22722839

Open questions

Whether OR5L1 represents a true cancer driver or a passenger mutation amplified by statistical analysis of a large gene family is unresolved PMID:22722839

Sources

PMID:22722839 — Prostate cancer WES, 112 tumors, Michigan cohort.

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