PAK3

Overview

PAK3 (p21-activated kinase 3) is a serine/threonine kinase in the PAK family that mediates signaling downstream of Rac and Cdc42 GTPases. It is involved in cytoskeletal organization, cell proliferation, and survival. In cancer genomics, PAK3 has been identified as a loss-of-function burden tumour suppressor candidate in desmoplastic melanoma.

Alterations observed in the corpus

• Loss-of-function burden tumour suppressor candidate in desmoplastic melanoma (along with FSIP1, CDH2, IL36A). PMID:26343386

Cancer types (linked)

• Desmoplastic melanoma (DMEL): LOF-burden tumour suppressor candidate. PMID:26343386

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26343386

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