PASK
Overview
PASK (PAS domain-containing serine/threonine kinase) is a metabolic sensor kinase that integrates energy status signals. In cancer genomics, PASK has been identified as recurrently mutated in lung squamous cell carcinoma with a striking sex-specific enrichment pattern.
Alterations observed in the corpus
- PASK mutations were identified with exclusive enrichment in males in lung SqCC (FDR q < 0.1) in the 1,144-tumor NSCLC landscape study (660 lung ADC, 484 lung SqCC); this is in contrast to RB1 mutations which were enriched in females in SqCC. PMID:27158780
Cancer types (linked)
- LUSC: PASK mutations exhibit sex-specific enrichment exclusively in males in the Campbell et al. 1,144-NSCLC WES study. PMID:27158780
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data available from current corpus.
Therapeutic relevance
- No direct therapeutic relevance reported in current corpus. The sex-specific mutation pattern may have implications for subgroup stratification in lung SqCC clinical trials.
Open questions
- The functional consequence of PASK mutations in lung squamous cell carcinoma and the mechanism underlying male-specific enrichment are not established.
Sources
This page was processed by crosslinker on 2026-05-14.