PDCD6

Overview

PDCD6 (Programmed Cell Death 6; also ALG-2) encodes a calcium-binding protein of the penta-EF-hand family involved in apoptotic signaling. In cancer genomics, it has been identified as a structural rearrangement partner near the TERT promoter in chromophobe renal cell carcinoma.

Alterations observed in the corpus

• Partner gene in one intrachromosomal TERT-promoter structural rearrangement in chromophobe RCC; rearrangement associated with >500-unit TERT expression upregulation PMID:25155756

Cancer types (linked)

• ChRCC: structural rearrangement partner with TERT promoter region PMID:25155756

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25155756

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